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News and Information Article
PITTSBURGH, Feb. 17 // -- Recombinomics is issuing a new
prediction and warning of a likely alteration in the avian influenza H5N1
hemagglutinin gene. Like the warning/prediction issued on October 22nd, 2005,
this new alteration will increase the virus affinity for human receptors and
lead to more efficient transmission of H5N1 to humans. The company has
notified the WHO of its prediction and warning regarding the near term
likelihood of this genetic alteration occurring.
In October, Recombinomics prediction/warning was based upon H5N1 entering
the Middle East via migratory birds, where another avian influenza, H9N2 was
endemic. Recombinomics, utilizing its patent pending approach, predicted that
the H gene in H5N1 would exchange genetic information with the H gene in H9N2
and would acquire the genetic change S227N (also called S223N). This
alteration had been previously shown to increase the affinity of H5N1 for
human receptors. In late December 2005, the first human infections by the
Qinghai strain of H5N1 were reported in Turkey. S227N was detected in the
index case for that outbreak with six additional cases confirmed four of whom
died.
Today, Recombinomics is predicting a similar change in the adjacent
position of the H5N1 virus receptor binding domain. The donor sequences are
again on the H, but in H1N1 European swine sequences. The new genetic change,
G228S, has also been previously shown to increase the affinity for human
receptors. Like H9N2 in the Middle East, H1N1 is endemic in swine populations
in Europe. Infection by H5N1 in H1N1 infected swine will allow the viruses to
exchange genetic information via recombination and allow H5N1 to acquire
S228N. The region of identity between H5N1 and H1N1 is downstream from the
S227N position, so H5N1, with and without the S227N change, can acquire this
new sequence. This sequence acquisition by the H5N1 virus will also lead to
more efficient transmission to humans.
"H5N1 is migrating into areas where it is encountering unique influenza
sero-types it has not encountered while largely confined to Asia over the past
few years. This expanded geographical reach allows H5N1 to exchange genetic
material with novel donor sequences, which under the appropriate selection
pressures, enables the genetic changes to become fixed in the genome of the
virus. H5N1 is in the process of acquiring genetic information that allows
for more efficient infections of humans", said Recombinomics President, Dr,
Henry Niman.
H5N1, like most rapidly evolving viruses, uses homologous recombination to
create novel genes that enhance the ability of the virus to evolve and remain
competitively viable. Recombinomics proprietary approach predicts these
changes and identifies novel gene targets for new vaccines, which in turn
allows manufacturers to develop vaccine in advance of the emergence of new
genetically altered, and potentially pandemic viral strains.
About Recombinomics, Inc. -- The Company was founded by Dr. Henry Niman, a
former Scripps Institute Assistant Member, based on his pioneering work in the
area of viral evolution. Dr. Nimans research identified recombination as
the underlying mechanism driving rapid genetic change, allowing him to file a
series of patents based on a deep understanding of this paradigm shifting
process. Recombinomics is in the process of commercializing its patent-pending
approach to significantly improve the standard vaccine development process.
Recombinomics, through its analysis and commentary section of its website
(http://www.recombinomics.com ), has been consistently ahead of both the
scientific community and government agencies in anticipating the genetic
evolution and geographic expansion of H5N1.
Contact Information:
Dr. Henry Niman
President
Recombinomics, Inc.
648 Field Club Road,
Pittsburgh, Pennsylvania 15238
Tel. 866.973.2662
henry_niman@recombinomics.com
Web Site: http://www.recombinomics.com
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