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News and Information Article
PITTSBURGH, Aug. 18 // -- Analysis of recently released H5N1
bird flu sequences from Indonesia and Hong Kong has revealed the geographic
movement and recombination of H5N1 in Southeast Asia. Indonesias Health
Minister recently approved the release of over 400 human sequences dating
back to July, 2005. Similarly, Hong Kong University released sequences from
Hong Kong dating back to February 2006.
This new data clearly indicates that H5N1 has been rapidly spreading
and evolving via recombination. The sequences from Hong Kong were the
Fujian strain, which has caused the recent reported human infections in
China. That strain has now spread throughout Southeast Asia. The sequences
from Indonesia indicated that all but one case outside of Karo have a novel
cleavage site that does not match public poultry sequences. Moreover, the
human sequences in Indonesia contain genetic sequences from both the Fujian
and Qinghai strains, which are accelerating the evolution of the H5N1
viruses. Recently, a new cluster in Garut Indonesia has been identified
Recombinomics will be presenting analysis of these genetic changes at
the Targeted Immunotherapeutics & Vaccine Summit in Cambridge,
Massachusetts on Monday, August 21. Recombinomics President, Henry L,
Niman, Ph.D. will present, "Pandemic and Seasonal Influenza Evolution Via
Recombination - Selection of Vaccine Targets" at 9:35 AM and will be on a
panel discussion on "Funding for Vaccines" at 4:30 PM.
"The talk will include the important acquisition of new sequences by
the various H5N1 strains in circulation as well as acquisitions by seasonal
flu. The recently released sequences from Indonesia have significantly
increased the influenza database available for analysis, which now provides
some striking examples of H5N1s recombination driven evolution," said
Henry Niman. He continued, "The newly released sequences demonstrate the
utility of a robust sequence database for tracing the origins of influenza
and selecting new vaccine targets for current vaccine production against
future and emerging strains."
Recombination is used by all rapidly evolving viruses, which creates a
major challenge in vaccine development as well as the timing of vaccine
production and distribution. Recombinomics has defined genetic acquisitions
rules, which are applicable in the vaccine development process so that
targets can be created prior to the emergence of new strains. The influenza
sequence database is expanding rapidly, providing additional examples of
various types of recombination, which can be exploited in the design of
effective vaccines.
Recombinomics, Inc. was founded by Dr. Henry Niman, a former Scripps
Institute Assistant Member, based on his pioneering work in the area of
viral evolution. Dr. Nimans research identified recombination as the
underlying mechanism driving rapid genetic change, allowing him to file a
series of patents based on a deep understanding of this paradigm shifting
process. Recombinomics is in the process of commercializing its
patent-pending approach to significantly improve the standard vaccine
development process. Recombinomics, through its analysis and commentary
section of its website (http://www.recombinomics.com), has been
consistently ahead of both the scientific community and government agencies
in anticipating the genetic evolution and geographic expansion of H5N1.
About The Targeted Immunotherapeutics & Vaccine Summit - Novel Vaccines
show promise for protecting humanity from the scourge of disease, yet their
worth is not always appreciated by the public, leading to shortfalls in
funding and product. This summit features talks from leading innovators in
the field of vaccines, ranging from cutting-edge research to breakthroughs
in transporting and administering vaccines throughout the world. The
conference is part of the Cambridge Healthtech Institutes conference
series.
Contact Information: Dr. Henry Niman
President
Recombinomics, Inc.
Tel. 866.973.2662
henry_niman@recombinomics.com
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